Formulation and Evaluation of Topical Hydrogel of Mometasone Furoate using Different Polymers

A gel can be described as the cross-linked material that retains a large amount of solvent inside its medium and if the solvent retained is water, such material is known as hydrogel. Drug therapy of the inflammation of skin is mainly topical. This necessitates the treatment of symptoms, since in most cases causal treatment is impossible due to unknown etiology. Topical corticosteroids are the most commonly used drugs in these skin conditions. Although there are many dosage forms available for the treatment of skin disorders, only lotions have shown to be suitable for hairy areas. Mometasone furoate (MOF) is a potent corticosteroid which presents an improved risk/benefit ratio. The aim of this work was to prepare a hydrogel formulation using various polymers like Carbopol-940, HPC, MC, Poloxamer-407, Sodium alginate, and HPMC with 0.1% (w/w) Mometasone furoate for scalp dermatitis. The formulated gel was evaluated for drug content, pH, viscosity, spreadability and in vitro drug release. Comparison of data obtained from successful gel formulation with marketed product. Spreadability of Carbopol gel containing Mometasone furoate (C1) was 26.76g.cm/sec as compared to 21.61g.cm/sec of marketed gel, indicating good spreadability of the prepared gel (C1). The percent drug release was 74.58 and 73.50 from C1 and marketed gel respectively. Stability studies under room temperature showed satisfactory results. It can be concluded that Carbopol gel containing Mometasone furoate showed good homogeneity, drug content, spreadability and stability and has wider prospect for topical preparations.